The FDA has expressly approved the use of Esketamine as a nasal spray for depressed people who are not responding to medicines. Esketamine is created by extracting a part of the ketamine molecule.
Because it is more effective, you might theoretically use it at a lesser dose and experience fewer negative effects. Given that the FDA has approved the therapy and that it is now obtainable in an intranasal
Esketamine must be provided in a clinical setting since it may lead to perceptional abnormalities for the first two hours after the therapy. Outpatient Esketamine nasal spray therapy is offered. Three doses of the nasal spray should be given, each five minutes apart, under a doctor’s supervision.
Game-Changing Treatment For Clinical Depression
Esketamine needs to be used in conjunction with a recognized antidepressant. The theory is that while the other medication works, Esketamine will immediately alleviate depression symptoms.
Esketamine is currently authorized for use in patients with depression who are resistant to therapy. This means that you have tried at least two other antidepressants and have not noticed remission or at least a 50% improvement in mood.
Esketamine’s antidepressant properties operate via a distinct mechanism from other medications. Natural molecules, including serotonin, norepinephrine, and dopamine, are elevated by traditional antidepressants.
These substances act as messengers, carrying messages between different brain cells. According to this notion, having more of these neurotransmitters improves brain cell communication and has a beneficial impact on the overall emotional state.
While Esketamine functions similarly to other antidepressants, it also raises levels of glutamate, the brain’s most prevalent chemical messenger. As a result, there is an increased effect on more brain cells at once. People with depression may need several weeks to detect a change in their symptoms.
The effects of Esketamine, on the other hand, are instantaneous and provide relief from depression symptoms within hours.
Traditional antidepressants have been demonstrated to raise suicidal thoughts at the start of therapy, especially in children and young people. According to Kaplin, the only medication that has been shown to reduce suicidal thoughts is Esketamine, which is the only alternative to lithium, which is frequently recommended for bipolar disorder. Although Esketamine is not currently authorized for this application, the FDA is still considering it.
Up to 33% of depressed people cannot be helped by conventional antidepressants. Clinical studies have shown that Esketamine helps most of these people have fewer depressive symptoms.
The sole other drug authorized for treating treatment-resistant depression is a combination of the antipsychotic drug olanzapine and the conventional antidepressant fluoxetine. However, the long-term effects of this medicine can be severe and include significant weight gain, metabolic problems, diabetes, and high blood pressure.
According to studies, untreated depression increases the risk of dementia and damages the brain over the long run; depressed people have hippocampus shrinkage of up to 20%. The hippocampus is a region of the brain that is crucial for memory and learning.
Esketamine, however, reverses these stress-related changes. It differs from other antidepressants in that, besides protecting the brain from the neurotoxic effects of depression, Kaplin claims that it also appears to have a growth-promoting impact.
You should anticipate the worst adverse effects during the first two sessions. After that, symptoms usually start to improve. Increased blood pressure, tiredness, and nausea are possible side effects. If you think your current depression treatment isn’t working, speak with your psychiatrist about Esketamine therapy.
Kaplin asserts that depression appears to have both a neuroprotective and a growth-promoting effect on the brain, in addition to shielding it from the neurotoxic effects of depression.
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