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Infants Immune Systems Found To Have Unique And Effective Responses To SARS-CoV-2

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Infants Immune Systems Found To Have Unique And Effective Responses To SARS-CoV-2

The University of Tubingen, Germany has been able to uncover some interesting facts about infants when it comes to their response to SARS-CoV-2. The study Multi-omics analysis of mucosal and systemic immunity to SARS-CoV-2 after birth was conducted with major participation from Stanford University, Emory University, and the Cincinnati Children’s Hospital Medical Center, U.S.

Extensive research shows infants and kids can hold their immunity for over 300 days. This is in direct contrast to what has been in adults and therefore the medical community believes it could be the beginning of something new.

Infants Immune Systems Found To Have Unique And Effective Responses To SARS-CoV-2

For the study, they studied over 125 samples that included infants and young children who were infected by Omicron and Non-Omicron variety of COVID-19. This was contrasted with samples collected from 48 adults and some expectant mothers as well.

It revealed, “ During the convalescent phase, 28 out of 30 infants and young children developed robust antibody responses which were durably maintained for the entire observation period of up to 300 days.

This contrasts with previous studies in adults that demonstrated a marked decay in the antibody response during the initial months following infection.” After that, they compared the production of antibodies in the infants and found that they “showed a small increase in absorbance after infection compared with pre-infection samples.

Similarly, we observed an increase in absorbance in acute infection samples compared with serum taken from matched mothers close to the time of birth.”The results were appalling as the infants have much weaker immune systems and are often infected by viruses in the Lungs.

In the next phase of the study, they decided to look for the memory in Kinetic T and B immune cells.  While in Omicron varieties, infant cells maintained S specific for 6 months, the adult cells had a longer memory of 8 months. Additionally, “the magnitude of the MBC(blood mononuclear cell)response in infants during acute infection was lower than in adults.”

The plasma cytokines response also produced similar results in infants but not in adults. When the plasmas from expectant mothers were compared they also showed similar results. In fact, some of them didn’t even need medication as compared to the adults. 

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The conclusion drawn by the recent study draws multiple parallels to a study conducted in 2021 by the University of Bristol and Bristol Royal Hospital for Children. They decided to conduct the study after they observed infants were not infected as compared to adult patients. Looking for the cause, they were able to uncover that infants have high immune cells and antibodies when COVID-19 attacks their bodies. 

It is no news that the beginning of the new decade was marked by the pandemic which is highly contagious.  Its common symptoms included cough, chest pain, loss of smell and taste high fever, and trouble breathing. Mortality was at an all-time high with over 67 Million being reported all over the world and no treatment was prescribed.

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Initially, the patients were isolated and were given medications for their symptoms. However, after a year now we have multiple vaccines that have been effective but their immunity is limited to a few months. So what does this new research mean? A doctor at the Bristol Royal Hospital was quoted saying, “This is very useful information for the design of future COVID-19 vaccines that could seek to induce and mimic the signature of this protective immunity.”

The only limitation is the extensiveness of the study. There could be various limitations based on the sample and the number of samples involved which could be taken care of in case the study goes global later.

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Cameron Reedwood is a seasoned and dedicated news reporter and writer known for his passion for investigative journalism and commitment to delivering accurate and thought-provoking stories to the public. With over two decades of experience in the field, he has established himself as a trusted voice in the world of journalism.

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